CBD research - Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption

2016: Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption

Our results suggest that CBD may have significant therapeutic benefits against diabetic complications and atherosclerosis.

Authors:

Rajesh M, Mukhopadhyay P, Bátkai S, Haskó G, Liaudet L, Drel VR, Obrosova IG, Pacher P.

Abstract:

A nonpsychoactive cannabinoid cannabidiol (CBD) has been shown to exert

potent anti-inflammatory and antioxidant effects and has recently been
reported to lower the incidence of diabetes in nonobese diabetic mice
and to preserve the blood-retinal barrier in experimental diabetes. In
this study we have investigated the effects of CBD on high glucose
(HG)-induced, mitochondrial superoxide generation, NF-kappaB activation,
nitrotyrosine formation, inducible nitric oxide synthase (iNOS) and
adhesion molecules ICAM-1 and VCAM-1 expression, monocyte-endothelial
adhesion, transendothelial migration of monocytes, and disruption of
endothelial barrier function in human coronary artery endothelial cells
(HCAECs). HG markedly increased mitochondrial superoxide generation
(measured by flow cytometry using MitoSOX), NF-kappaB activation,
nitrotyrosine formation, upregulation of iNOS and adhesion molecules
ICAM-1 and VCAM-1, transendothelial migration of monocytes, and
monocyte-endothelial adhesion in HCAECs. HG also decreased endothelial
barrier function measured by increased permeability and diminished
expression of vascular endothelial cadherin in HCAECs. Remarkably, all
the above mentioned effects of HG were attenuated by CBD pretreatment.
Since a disruption of the endothelial function and integrity by HG is a
crucial early event underlying the development of various diabetic
complications, our results suggest that CBD, which has recently been
approved for the treatment of inflammation,
pain, and spasticity associated with multiple sclerosis in humans, may
have significant therapeutic benefits against diabetic complications and
atherosclerosis.

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