Parker LA, Mechoulam R, Schlievert C.
Rats display conditioned rejection reactions during an oral infusion of a
flavor previously paired with an emetic drug; considerable evidence
indicates that these rejection reactions reflect nausea. Here we report
that cannabidiol, a major non-psychoactive cannabinoid found in
marijuana and its synthetic dimethylheptyl homolog interfere with nausea
elicited by lithium chloride and with conditioned nausea elicited by a
flavor paired with lithium chloride. These results suggest that
cannabinoids without psychoactive side-effects may have therapeutic
value in the treatment of chemotherapy-induced nausea.